Inflammation promotes prostate differentiation: Fig. 1.

Inflammation promotes prostate differentiation.

Inflammation has been linked to a number of diseases including prostate cancer, but the mechanisms by which inflammatory signaling promotes tumorigenesis remain largely unknown (1). In PNAS, Kwon et al. (2) demonstrate that bacterial-induced inflammation in the mouse prostate is associated with both proliferation and basal-to-luminal differentiation, the limiting step in the transformation of b...

Fig. 1

Differentiation Of Granulomatous Prostatitis From Prostate Carcinoma

  Background and Objective: Non-specific granulomatous prostatitis is an uncommon diffuse inflammatory condition of the prostate. It is important because it may be mistaken for prostatic carcinoma. The aim of the study was to determine the prevalence of non-specific granulomatous prostatitis (NSGP) and comparing the results of transrectal ultrasonography, serum prostate specific antigen (PSA) ...

IRF-1 promotes inflammation early after ischemic acute kidney injury.

Acute renal ischemia elicits an inflammatory response that may exacerbate acute kidney injury, but the regulation of the initial signals that recruit leukocytes is not well understood. Here, we found that IFN regulatory factor 1 (IRF-1) was a critical, early proinflammatory signal released during ischemic injury in vitro and in vivo. Within 15 min of reperfusion, proximal tubular cells of the S...

Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression.

Recent studies have indicated that a high-fat diet (HFD) plays an important role in prostate cancer (PCa) progression. Palmitic acid (PA) is one of the most abundant saturated free fatty acids (FAs) and is associated with carcinogenesis. In this study, we investigated the mechanism underlying the association of dietary fat, including PA, with PCa progression. In four PCa cell lines, in vitro PA...